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                                          钱柜平台

                                          移動站  | 2019年04月28日 星期日
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                                          基本信息:

                                          姓名: 吳息鳳
                                          職務: 公共衛生系主任  ;钱柜平台附屬第二醫院副院長;钱柜健康醫療大數據國家研究院院長
                                          職稱: 教授
                                          學歷: 博士
                                          專業: 1.分子流行病學 ,2.腫瘤流行病學
                                          所屬院系: 公共衛生系
                                          研究方向: 腫瘤分子流行病學 , 健康醫療大數據,生物標誌物 , 精準醫學 , 風險預測人工智能
                                          電話:
                                          信箱: xifengw@zju.edu.cn
                                          個人主頁: https://person.zju.edu.cn/0019030

                                          個人簡介:

                                          1984年獲復旦大學(原上海第一钱柜平台)醫學學位 ,1987年獲钱柜(原浙江醫科大學)碩士學位 ,1991年在法國獲得博士後,1994年從德州大學公共衛生學院獲得博士學位。1995年起至2019年任職於美國癌症醫院歷年排名第一的德州大學MD安德森癌症中心 ,兼任德克薩斯大學公共衛生學院流行病學教授 。2004年開始授予終身教授,2006年開始授予Ashbel Smith Professorship冠名教授 ,2008年起至2019獲得癌症預防Betty B. Marcus冠名主席 ,2010年起至2019擔任癌前基因組圖譜計劃主任,轉化醫學和公衆健康基因組學中心主任包括血液樣本庫和個體化風險預測項目,2011年起至2019擔任病史數據庫主任 。2011年起至2015擔任流行病學系系主任和流行病學學科負責人。

                                          作爲一名擁有多學科知識背景和創新理念的科學家 ,吳教授使用高度創新  ,循證醫學 ,和整合的戰略建立一系列的大數據,大型樣本庫,發現和驗證可改變腫瘤危險因素,篩選癌症藥物遺傳生物標誌物,利用高端的生物信息和生物統計方法建立整合性的風險預測模型並轉成一系列的基於互聯網的個人預測模型的人工智能工具,建立高危人羣早期識別方法 ,爲制定有針對性個體化的精準腫瘤預防和治療領域做出了卓越的貢獻 ,她領導的團隊成爲該領域的世界頂尖團隊之一 。

                                          吳教授的團隊建立了一系列大型的樣本庫、數據庫、隊列和風險預測模型 ,包括:1) MD安德森癌症中心病史資料庫:系統地收集在MD安德森癌症中心進行治療的腫瘤患者的流行病學和臨牀數據,併成功實現了採集過程的電子化 。到目前爲止,已經收集了超過55萬例患者的資料;2) MD 安德森癌症中心腫瘤患者血液標本研究資源庫:採集所有在MD安德森癌症中心新登記的腫瘤患者的血液樣本 ,並進行處理和存儲。到目前爲止,已經收集了11萬多名腫瘤患者的DNA、血清和全血標本 ;3)美兆人羣健康篩查隊列(MJ Cohort):臺灣健康管理機構美兆收集了100餘萬人的體檢資料和詳細的基線調查問卷數據,存儲了超過10萬參與者的血樣,與美兆合作 ,吳教授建立了多個全方位整合腫瘤風險預測模型 ;4)MD安德森癌症中心癌前病變病人隊列:作爲MD安德森癌症中心癌前病變基因組圖譜項目的負責人,領導建立了癌前病變生物樣本庫以及相應的研究技術平臺 ,納入了三種明確的癌前病變,包括結直腸腺瘤、Barrett食管和口腔癌前病變等;5) MD安德森癌症中心腫瘤患者隊列(MDA- CPSC):樣本庫與腫瘤患者血液標本資源庫、完善的病史資料庫以及先進的實驗室相結合,組成了世界一流的腫瘤流行病學和轉化醫學研究的平臺。至今MDA-CPSC隊列已經超過20萬病例 ;6) MD安德森癌症中心腫瘤倖存者隊列:目前已招募了超過8500例長期存活的腫瘤患者 。同時還與兒科合作,收集新診斷的兒童腫瘤病人的血液標本,建立了兒童腫瘤患者生物樣本庫 ;7) 世界領先的腫瘤流行病學實驗室:集合數據收集中心、標本處理中心、分子流行病學實驗室、基因分型檢測中心、實驗及臨牀數據管理中心、統計分析中心爲一體,是MD 安德森癌症中心最大的實驗室之一 ;8) 美國最大之一的肺癌、膀胱癌、食道癌和腎癌的病例對照研究,以及臨牀轉歸流行病研究 。吳教授制定了嚴格的規章制度來利用和管理這些資源  ,建立了樣本和資料使用委員會來評審和批准樣本和資料的使用 。該委員會已經批准了來自26個部門的130個項目申請,極大地促進了MD安德森癌症中心的科研 。以這些平臺爲依託,吳教授幫助年輕的教授們於2015年獲得了4項美國國家癌症研究中心R01基金的資助進行全外顯子測序(WES)腫瘤的少見基因變異等課題 ;三年時間內獲得了三千七百萬美元的科研基金。這些都充分證明了吳教授的領導才能 。

                                          創新的理念和不懈的追求使吳教授的團隊一直處於癌症分子流行病研究和分子標誌物發現的世界領先地位 , 也受到美國國立癌症研究所(NCI)和同行的廣泛認可。她一直是MD安德森癌症中心和整個美國癌症流行病領域收到NCI科研基金資助最多的研究者之一 。她這20年共獲得基金資助總額超過一億美金,包括16項美國國家癌症研究中心重大項目基金和30項R01基金,充分證明了吳教授團隊的研究處於美國和世界領先地位。迄今爲止  ,她已發表論文超過545篇包括自然遺傳 ,柳葉刀 ,柳葉刀腫瘤學 ,美國醫學會雜誌,英國醫學期刊 ,國家癌症研究所雜誌,臨牀腫瘤學雜誌 ,新英格蘭醫學,自然等全球知名期刊。

                                          她的挑戰性研究表明,每天15分鐘的適量運動可降低死亡率14%並延長三年的壽命,每多鍛鍊15分鐘就進一步降低4%的總死亡率和1%的癌症死亡率 ,這導致她提出了MPOWER的措施來減輕不活動導致的健康負擔 (Lancet, 2011, 2012, 2013, 2015 ,IF:53.3)。她發現慢性病導致的超過五分之一的癌症發病和超過三分之一的癌症死亡率風險,這與五大生活方式因素導致的總風險相似。患有慢性疾病風險評分最高的個體的壽命縮短了近16年。認識到這種被忽視的癌症風險可能會改變目前的癌症預防策略並激勵更好地控制慢性病。幸運的是,身體活動可能會使與慢性病相關的癌症風險降低近40% (British Medical Journal,2018 IF:28) 。她和她的合作團隊發現、簽定、和證實了多個新的腫瘤遺傳易感位點包括肺癌 ,膀胱癌 ,腎癌  ,卵巢癌 ,睾丸癌和淋巴瘤 ,(Nature Genetics, 2008, 2009, 2010, 2011, 2012, 2013, and 2014,IF:27.1; Nature Communication, 2015, 2016, 2016, 2017 ,IF:12.3; Lancet Oncology, 2010 IF:36.4; Cancer Discovery, 2011 IF:24.4  ;American Journal of Human Genetics 2014;IF:8.86; Clinical Cancer Research 2010, 2017, IF:10.2; Human Molecular Genetics, 2011, 2012, 2013, 2014, 2016,IF:4.9),以及與肺癌患者生存相關的基因位點(Journal of National Cancer Institute, 2011, IF:12.2; Cancer Research, 2013, 2014  ,IF:9.1)。她利用GWAS發現了一個全新的膀胱癌易感基因PSCA。該項目包括3個美國研究現場 ,9個歐洲研究現場,以及一個日本研究室。研究發現PSCA基因上的1 個錯義突變可導致膀胱癌發病風險增加15% ;通過基因重新測序和體外功能學試驗 ,證實該突變與膀胱癌可能存在病因學聯繫(Nature Genetics,2009 IF: 27.1) 。作爲主要的研究人員 ,她利用全基因組關聯研究(GWAS)發現人類染色體15q25區域的菸鹼乙酰膽鹼受體亞單位單核苷酸多態是肺癌易感性位點 (Nature Genetics,2008 ,IF: 27.1)。她發現了一組在腺瘤和CRC之間具有獨特突變模式的基因以及用於早期檢測的潛在生物標誌物 ,其可以作爲進展的驅動因子。創建了一個20基因突變小組,最佳區分腺瘤和CRC,預測準確度爲0.93(Gut,2017, IF:17.0) 。 她利用多維數據集成構建了一系列的個體化風險預測模型: 膀胱癌的(Journal of National Cancer Institute,2007, IF:12.2),肝癌(Journal of National Cancer Institute,2012, IF:12.2),肺癌(Scientific Reporter,2016 , IF: 4.1) ,乳腺癌復發(Journal of National Cancer Institute ,2017, IF:12.2),輻射毒性(Clinical Pharmacology & Therapeutics,2017, IF: 7.3)和肺癌復發(Clinical Pharmacology & Therapeutics ,2017, IF: 7.3 ) 。

                                          吳教授獲得了MD安德森傑出學者獎,德州大學阿什貝爾史密斯冠名教授,瑪格麗特和小詹姆斯答:埃爾金斯癌症預防學成就獎 ,朱莉和本羅傑斯卓越研究獎 ,貝蒂B. 癌症預防冠名主席,MD安德森研究信託高級研究員,羅伯特·張伯倫傑出導師獎 ,休斯敦50位最有影響力的女性 ,以及癌症預防傑出導師獎等多項榮譽 。她擔任許多美國和國際科研機構的資金評審委員包括美國國家癌症研究所,歐盟研究委員會 ,英國癌症研究,中國國家分子轉化中心 , 意大利 ,波蘭,西班牙,新加坡  ,法國,等許多國家和國際撥款審查 。

                                          吳教授擔任多名年輕員工、博士生、博士後和臨牀醫生的指導老師 。她多次獲得最佳團隊領導和最佳導師獎。她共培養研究生50名、博士後33名、臨牀醫生和訪問學者43人。其中有61人次獲得美國癌症研究學會(AACR)青年學者獎等各類學術榮譽和獎勵。多名訪問學者歸國後成爲各自單位的骨幹力量;她指導和協助流行病學系多位年輕科研人員獨立申請並獲得National Institute of Health的重大基金資助。她所指導的博士後研究人員成爲衆多科研機構爭選的對象 。

                                           

                                          研究方向 腫瘤分子流行病學  , 健康醫療大數據,生物標誌物 , 精準醫學, 風險預測人工智能

                                           

                                          工作研究項目

                                          擔任美國國家健康中心重大項目的主持人或共同主持人

                                          1.     Project Leader, University of Texas LUNG SPORE – Project 2: Epidemiologic Studies of Germline Polymorphisms in miRNA Pathways to Determine Their Role in Risk of Lung Cancer Development and Recurrence, P50 CA070907, NIH/NCI, ~ $1,120,000

                                          2.     Principal Investigator-MDACC, Breast Cancer Genetic Study in African Ancestry Populations, R01 CA202981, Vanderbilt University - NIH/NCI, 7/1/2016-6/30/2021 ,  ~$60  ,000

                                          3.     Principal Investigator, Epigenetic miRNA, SNP Signatures, and their Functions in Lung Cancer Outcomes, R01 CA176568, NIH/NCI, 4/1/2014-2/28/2019, ~$1,564,436

                                          4.     Principal Investigator, PQ-A4 Point-of-Care Test of Exposure to Hepatocellular Carcinoma Risk by V-Chip, R01 CA180083, NIH/NCI, 9/10/2013-6/30/2018, ~$2,707,563

                                          5.     Principal Investigator, Molecular Pathways Linking Obesity and RCC Tumorigenesis (PQ1), R01 CA170298, NIH/NCI, 9/1/2012-6/30/2018, ~$2,800,000

                                          6.     Principal Investigator-MDACC, Genetic Epidemiology of non-Hodgkin Lymphoma, R01 CA200703, Mayo Clinic - NIH/NCI, 7/8/2016-5/31/2021, ~$551,630

                                          7.     Principal Investigator, Role of MicroRNA in Lung Cancer Risk & Clinical Outcome Prediction, RP130502, Cancer Prevention & Research Institute of Texas (CPRIT), 6/1/2013-5/30/2017, ~$1,294,346

                                          8.     Principal Investigator-MDACC, Telomere Length and the Risk of Cancer and Diabetes: A Prospective Longitudinal Study, Sister Institution Network Fund, MD Anderson Cancer Center, 11/15/2011-11/14/2013, ~$100,000

                                          9.     Principal Investigator, Prostate SPORE: Project 5. Separating the Chaff from the Wheat: Identifying Patients at Minimal Risk for Prostate Cancer Progression, CA140388-04, NIH/NCI,9/1/2012-8/31/2014,  ~$320,596

                                          10.  Multiple Principal Investigator, Transdisciplinary Research in Cancer of the Lung (TRICL), U19 CA148127, NIH/NCI, 7/9/2010-6/30/2014, ~$4,559,755

                                          11.  Principal Investigator - Project 2, University of Texas SPORE in Lung Cancer. Project 2: Risk Prediction for Platinum-based Chemotherapy and Radiotherapy Outcome in Non-Small Cell Lung Cancer Patients, P50 CA070907, NIH/NCI, 9/1/2009-8/31/2014, ~$1,120,000

                                          12.  Principal Investigator, Lung Cancer Chemoradiation: Predictors of Survival, CA111646-05S1, NIH/NCI, 2009-2010, ~$243,158

                                          13.  Principal Investigator - Project 2, University of Texas SPORE in Head and Neck Cancer, Project 2: Cancer Risk Assessment in Patients with Oral Premalignant Lesions: An Integrative Approach, P50 CA097007, NIH/NCI, 8/1/2008-7/31/2014, ~$1,323,521

                                          14.  Principal Investigator, Genetic Instability and Risk for Esophageal Carcinoma, R01 CA111922, NIH/NCI, 3/10/2008-1/31/2015, ~$2,860,710

                                          15.  Principal Investigator, Genome-Wide Association Analysis of Bladder Cancer, U01 CA127615, NIH/NCI, 4/1/2008-3/31/2015, ~$4,803,014

                                          16.  Principal Investigator: Project 2, GU SPORE Project 2. Markers of Susceptibility as Predictors of Bladder Cancer Recurrence, P50 CA091846, NIH/NCI, 9/25/2006-8/31/2012, ~$1,360,000

                                          17.  Principal Investigator: Project 4, Molecular Epidemiology and Pharmacogenomics in Oral Carcinogenesis, P01 CA106451, NIH/NCI, 8/1/2004-7/31/2009, ~$922,932

                                          18.  Principal Investigator, Genetic Susceptibility to Bladder Cancer, R01 CA074880, NIH/NCI, 2004-2009, ~$1,753,658

                                          19.  Principal Investigator: Project 4, Molecular Epidemiology and Pharmacogenomics in Oral Carcinogenesis, P01 CA106451, NIH/NCI, 8/1/2004-7/31/2009, ~$922,932

                                          20.  Principal Investigator, Genetic Susceptibility Modifiers in Renal Cell Carcinoma, R01 CA098897, NIH/NCI, 8/1/2003-7/31/2008, ~$2,512,529

                                          21.  Principal Investigator ,Project 2, GU SPORE, Markers of Susceptibility as Predictors of Bladder Cancer Recurrence, P50 CA091846, NIH/NCI, 9/25/2001-8/31/2006, ~$1,967,363

                                          22.  Project Leader, SPORE in Genitourinary Cancer - Project 2: Role of MicroRNA in Bladder Cancer Risk and Outcome: A Genome-wide Analysis, P50 CA091846, NIH/NCI, 9/25/2001-8/31/2017, ~1,100,000

                                          23.  Principal Investigator, Genetic Influence on Mutagen Sensitivity: A Twin Study, R01 CA085576, NIH/NCI, 5/4/2001-4/30/2005, ~$1,500,000

                                          擔任美國國家健康中心重大項目的合作人

                                          1.     Co-Investigator, Next generation sequencing to identify novel colorectal cancer genes, R01 CA177935, NIH/NCI, 6/5/2014-4/30/2019, ~$2,558,150

                                          2.     Co-Investigator, Discovery of Risk Loci and Genomics of Pancreatic Cancer through Exome Sequencing, R01 CA181244, NIH/NCI, 7/11/2014-5/31/2019, ~$4,166,466

                                          3.     Co-Principal Investigator, DNA methylation and telomere length in peripheral blood as predictors of aggressive prostate cancer, RP140556, Cancer Prevention & Research Institute of Texas (CPRIT), 9/1/2014-8/30/2018, ~$853,787

                                          4.     Co-Investigator, High-throughput sequencing to identify novel melanoma susceptibility genes, R01 CA195614, NIH/NCI, 6/1/2015-5/31/2020, ~$3,686,884

                                          5.     Co-Investigator, Discovery of Novel Rare Variants as Ovarian Cancer Susceptibility Factors, R01 CA188943, NIH/NCI, 8/1/2015-7/31/2020, ~$4,821,510

                                          Numerous other grants are not listed here.

                                           

                                          研究與成果

                                          吳教授使用高度創新 ,循證醫學 ,和整合的戰略的策略來構建一系列的大數據,大型樣本庫,發現新的行爲風險因素,生物標誌物 ,並通過基於證據的人工智能在癌症連續體中創建強大的預測模型,從而爲推動精準健康做出了有力的貢獻 。她擁有出色的資金記錄 ,一直是MD安德森癌症中心和整個美國癌症領域收到美國國家健康中心科研基金資助最多的研究者之一,近年來共承擔項目49項  ,其中主持項目30項 ,主持項目經費共超過4940萬美元。20年共獲得基金資助總額超過一億美金 。包括16項美國國家癌症研究中心重大項目基金和30項重點(R01)基金。發表論文545餘篇, 包括SCI收錄論文530餘篇 。 擔任許多美國和國際科研機構的資金評審委員 。

                                           

                                          發表論文 (Selected from over 545 manuscripts and book chapters):

                                          建立一系列的大數據,大型樣本庫

                                          l  Wu X, Tsai SP, Tsao CK, Chiu ML, Tsai MK, Lu PJ, Lee JH, Chen CH, Wen C, Chang SS, Hsu CY, Wen CP. Cohort Profile: The Taiwan MJ Cohort: half a million Chinese with repeated health surveillance data. Int J Epidemiol. e-Pub 2/2017. PMID: 28204597.

                                          l  Chow WH, Chrisman M, R Daniel C, Ye Y, Gomez H, Dong Q, Anderson CE, Chang S, Strom S, Zhao H, Wu X.. Cohort Profile: The Mexican American Mano a Mano Cohort. Int J Epidemiol. e-pub Mar 8, 2015. PMID: 25747868.

                                          l  Wu X, Hildebrandt MA, Ye Y, Chow WH, Gu J, Cunningham S, Zhao H, Hawk ET, Wagar E, Rodriguez A, Hamilton SR. Cohort Profile: The MD Anderson Cancer Patients and Survivors Cohort (MDA-CPSC). Int J Epidemiol. e-Pub 12/2015. PMID: 26686840.

                                          發現和驗證腫瘤相關行爲危險因素

                                          l  Tu H, Wen CP, Tsai SP, Chow WH, Wen C, Ye Y, Zhao H, Tsai MK, Huang M, Dinney CP, Tsao CK, Wu X. Cancer risk of chronic diseases and disease markers: a prospective cohort study of 405,878 individuals. British Medical Journal, 360:k134. doi: 10.1136/bmj.k134, 2018 Jan 31, PMID: 29386192.

                                          l  Tu H, Dinney CP, Ye Y, Grossman HB, Lerner S, Wu X. Is folic acid safe? An evidence-based study in non-muscle-invasive bladder cancer patients. Am J Clin Nutr. 107(2):208-216, 2018 Feb 1. PMID: 29529165.

                                          l  Melkonian SC, Daniel CR, Ye Y, Pierzynski JA, Roth JA, Wu X. Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites. Cancer Epidemiol Biomarkers Prev. 25(3):532-9, 2016. PMID:26944871.

                                          l  Melkonian SC, Daniel CR, Hildebrandt MA, Tannir NM, Ye Y, Chow WH, Wood CG, Wu X. Joint association of genome-Wide association study-identified susceptibility loci and dietary patterns in risk of renal cell carcinoma among non-Hispanic whites. Am J Epidemiol. 180(5): 499-507, 2014 . PMCID: PMC4143080.

                                          l  Shu X, Lin J, Wood CG, Tannir NM, Wu X. Energy Balance, Polymorphisms in the mTOR Pathway, and Renal Cell Carcinoma Risk. J Natl Cancer Inst 105(6):424-32, 3/2013. PMCID: PMC3601952.

                                          l  Wen CP, Tsai MK, Wai JP, Wu X. Promoting increased physical activity and reduced inactivity - Authors' reply. Lancet 381(9861):114-5, 1/2013. PMID: 23312751.

                                          l  Wen CP, Wai JP, Tsai MK, Yang YC, Cheng TY, Lee MC, Chan HT, Tsao CK, Tsai SP, Wu X. Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet 378(9798):1244-53, 10/2011. PMID: 21846575.

                                          篩選癌症藥物遺傳生物標誌物

                                          l  Lin SH, Raju GS, Huff C, Ye Y, Gu J, Chen JS, Hildebrandt MAT, Liang H, Menter DG, Morris J, Hawk E, Stroehlein JR, Futreal A, Kopetz S, Mishra L, Wu X. The somatic mutation landscape of premalignant colorectal adenoma. Gut, 67(7):1299-1305, 2018 Jul. PMID: 28607096.

                                          l  Tu H, Sun L, Dong X, Gong Y, Xu Q, Jing J, Bostick RM, Wu X, Yuan Y. A Serological Biopsy Using Five Stomach-Specific Circulating Biomarkers for Gastric Cancer Risk Assessment: A Multi-Phase Study. Am J Gastroenterol 112(5):704-715, 5/2017. PMID: 28323271.

                                          l  Scelo G, Purdue MP, Brown KM, Johansson M, Wang Z, Eckel-Passow JE, Ye Y, Hofmann JN, Choi J, Foll M, Gaborieau V, Machiela MJ, Colli LM, Li P, Sampson JN, Abedi-Ardekani B, Besse C, Blanche H, Boland A, Burdette L, Chabrier A, Durand G, Le Calvez-Kelm F, Prokhortchouk E, Robinot N, Skryabin KG, Wozniak MB, Yeager M, Basta-Jovanovic G, Dzamic Z, Foretova L, Holcatova I, Janout V, Mates D, Mukeriya A, Rascu S, Zaridze D, Bencko V, Cybulski C, Fabianova E, Jinga V, Lissowska J, Lubinski J, Navratilova M, Rudnai P, Szeszenia-Dabrowska N, Benhamou S, Cancel-Tassin G, Cussenot O, Baglietto L, Boeing H, Khaw KT, Weiderpass E, Ljungberg B, Sitaram RT, Bruinsma F, Jordan SJ, Severi G, Winship I, Hveem K, Vatten LJ, Fletcher T, Koppova K, Larsson SC, Wolk A, Banks RE, Selby PJ, Easton DF, Pharoah P, Andreotti G, Freeman LEB, Koutros S, Albanes D, Männistö S, Weinstein S, Clark PE, Edwards TL, Lipworth L, Gapstur SM, Stevens VL, Carol H, Freedman ML, Pomerantz MM, Cho E, Kraft P, Preston MA, Wilson KM, Michael Gaziano J, Sesso HD, Black A, Freedman ND, Huang WY, Anema JG, Kahnoski RJ, Lane BR, Noyes SL, Petillo D, Teh BT, Peters U, White E, Anderson GL, Johnson L, Luo J, Buring J, Lee IM, Chow WH, Moore LE, Wood C, Eisen T, Henrion M, Larkin J, Barman P, Leibovich BC, Choueiri TK, Mark Lathrop G, Rothman N, Deleuze JF, McKay JD, Parker AS, Wu X (co-last author), Houlston RS, Brennan P, Chanock SJ. Genome-wide association study identifies multiple risk loci for renal cell carcinoma. Nat Commun, 2017 Jun 9;8:15724. doi: 10.1038/ncomms15724. PMID: 28598434.

                                          l  Berndt SI, Camp NJ, Skibola CF, Vijai J, Wang Z, Gu J, Nieters A, Kelly RS, Smedby KE, Monnereau A, Cozen W, Cox A, Wang SS, Lan Q, Teras LR, Machado M, Yeager M, Brooks-Wilson AR, Hartge P, Purdue MP, Birmann BM, Vajdic CM, Cocco P, Zhang Y, Giles GG, Zeleniuch-Jacquotte A, Lawrence C, Montalvan R, Burdett L, Hutchinson A, Ye Y, Call TG, Shanafelt TD, Novak AJ, Kay NE, Liebow M, Cunningham JM, Allmer C, Hjalgrim H, Adami HO, Melbye M, Glimelius B, Chang ET, Glenn M, Curtin K, Cannon-Albright LA, Diver WR, Link BK, Weiner GJ, Conde L, Bracci PM, Riby J, Arnett DK, Zhi D, Leach JM, Holly EA, Jackson RD, Tinker LF, Benavente Y, Sala N, Casabonne D, Becker N, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Chaffee KG, Achenbach SJ, Vachon CM, Goldin LR, Strom SS, Leis JF, Weinberg JB, Caporaso NE, Norman AD, De Roos AJ, Morton LM, Severson RK, Riboli E, Vineis P, Kaaks R, Masala G, Weiderpass E, Chirlaque MD, Vermeulen RC, Travis RC, Southey MC, Milne RL, Albanes D, Virtamo J, Weinstein S, Clavel J, Zheng T, Holford TR, Villano DJ, Maria A, Spinelli JJ, Gascoyne RD, Connors JM, Bertrand KA, Giovannucci E, Kraft P, Kricker A, Turner J, Ennas MG, Ferri GM, Miligi L, Liang L, Ma B, Huang J, Crouch S, Park JH, Chatterjee N, North KE, Snowden JA, Wright J, Fraumeni JF, Offit K, Wu X (co-last author), de Sanjose S, Cerhan JR, Chanock SJ, Rothman N, Slager SL. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Nat Commun 7:10933, 3/2016. PMCID: PMC4786871.

                                          l  Mendoza-Pérez J, Gu J, Herrera LA, Tannir NM, Matin SF, Karam JA, Huang M, Chang DW, Wood CG, Wu X. Genomic DNA hypomethylation and risk of renal cell carcinoma: A case-control study. Clin Cancer Res 22(8):2074-82, 4/2016. PMCID: PMC4834236.

                                          l  Wen CP, Zhang F, Liang D, Wen C, Gu J, Skinner H, Chow WH, Ye Y, Pu X, Hildebrandt MA, Huang M, Chen CH, Hsiung CA, Tsai MK, Tsao CK, Lippman SM, Wu X. The ability of bilirubin in identifying smokers with higher risk of lung cancer: a large cohort study in conjunction with global metabolomic profiling. Clin Cancer Res 21(1):193-200, 1/2015. PMCID: PMC4286447.

                                          l  Cerhan JR, Berndt SI, Vijai J, Ghesquières H, McKay J, Wang SS, Wang Z, Yeager M, Conde L, de Bakker PI, Nieters A, Cox D, Burdett L, Monnereau A, Flowers CR, De Roos AJ, Brooks-Wilson AR, Lan Q, Severi G, Melbye M, Gu J, Jackson RD, Kane E, Teras LR, Purdue MP, Vajdic CM, Spinelli JJ, Giles GG, Albanes D, Kelly RS, Zucca M, Bertrand KA, Zeleniuch-Jacquotte A, Lawrence C, Hutchinson A, Zhi D, Habermann TM, Link BK, Novak AJ, Dogan A, Asmann YW, Liebow M, Thompson CA, Ansell SM, Witzig TE, Weiner GJ, Veron AS, Zelenika D, Tilly H, Haioun C, Molina TJ, Hjalgrim H, Glimelius B, Adami HO, Bracci PM, Riby J, Smith MT, Holly EA, Cozen W, Hartge P, Morton LM, Severson RK, Tinker LF, North KE, Becker N, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, Staines A, Lightfoot T, Crouch S, Smith A, Roman E, Diver WR, Offit K, Zelenetz A, Klein RJ, Villano DJ, Zheng T, Zhang Y, Holford TR, Kricker A, Turner J, Southey MC, Clavel J, Virtamo J, Weinstein S, Riboli E, Vineis P, Kaaks R, Trichopoulos D, Vermeulen RC, Boeing H, Tjonneland A, Angelucci E, Di Lollo S, Rais M, Birmann BM, Laden F, Giovannucci E, Kraft P, Huang J, Ma B, Ye Y, Chiu BC, Sampson J, Liang L, Park JH, Chung CC, Weisenburger DD, Chatterjee N, Fraumeni JF, Slager SL, Wu X(co-last author), de Sanjose S, Smedby KE, Salles G, Skibola CF, Rothman N, Chanock SJ. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Nat Genet 46(11):1233-8, 11/2014. PMCID: PMC4213349.

                                          l  Pu X, Ye Y, Spitz MR, Wang L, Gu J, Lippman SM, Hildebrandt MA, Hong WK, Minna JD, Roth JA, Yang P, Wu X. Predictors of survival in never-smokers with non-small cell lung cancer: a large-scale, two-phase genetic study. Clin Cancer Res 18(21):5983-91, 11/2012. PMCID: PMC3640870.

                                          l  Wu X, Ye Y, Rosell R, Amos CI, Stewart DJ, Hildebrandt MA, Roth JA, Minna JD, Gu J, Lin J, Buch SC, Nukui T, Ramirez Serrano JL, Taron M, Cassidy A, Lu C, Chang JY, Lippman SM, Hong WK, Spitz MR, Romkes M, Yang P. Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy. J Natl Cancer Inst 103(10):817-25, 5/2011. PMCID: PMC3096796.

                                          l  Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X (co-first author), Figueroa JD, Real FX, Van Den Berg D, Matullo G, Baris D, Thun M, Kiemeney LA, Vineis P, De Vivo I, Albanes D, Purdue MP, Rafnar T, Hildebrandt MA, Kiltie AE, Cussenot O, Golka K, Kumar R, Taylor JA, Mayordomo JI, Jacobs KB, Kogevinas M, Hutchinson A, Wang Z, Fu YP, Prokunina-Olsson L, Burdett L, Yeager M, Wheeler W, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G, Grubb R, Black A, Jacobs EJ, Diver WR, Gapstur SM, Weinstein SJ, Virtamo J, Cortessis VK, Gago-Dominguez M, Pike MC, Stern MC, Yuan JM, Hunter DJ, McGrath M, Dinney CP, Czerniak B, Chen M, Yang H, Vermeulen SH, Aben KK, Witjes JA, Makkinje RR, Sulem P, Besenbacher S, Stefansson K, Riboli E, Brennan P, Panico S, Navarro C, Allen NE, Bueno-de-Mesquita HB, Trichopoulos D, Caporaso N, Landi MT, Canzian F, Ljungberg B, Tjonneland A, Clavel-Chapelon F, Bishop DT, Teo MT, Knowles MA, Guarrera S, Polidoro S, Ricceri F, Sacerdote C, Allione A, Cancel-Tassin G, Selinski S, Hengstler JG, Dietrich H, Fletcher T, Rudnai P, Gurzau E, Koppova K, Bolick SC, Godfrey A, Xu Z, Sanz-Velez JI, D García-Prats M, Sanchez M, Valdivia G, Porru S, Benhamou S, Hoover RN, Fraumeni JF, Silverman DT, Chanock SJ. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet 42(11):978-84, 11/2010. PMCID: PMC3049891.

                                          l  Li Y, Sheu CC, Ye Y, de Andrade M, Wang L, Chang SC, Aubry MC, Aakre JA, Allen MS, Chen F, Cunningham JM, Deschamps C, Jiang R, Lin J, Marks RS, Pankratz VS, Su L, Li Y, Sun Z, Tang H, Vasmatzis G, Harris CC, Spitz MR, Jen J, Wang R, Zhang ZF, Christiani DC, Wu X (co-last author), Yang P. Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol 11(4):321-30, 4/2010. PMCID: PMC2945218.

                                          l  Wu X, Ye Y, Kiemeney LA, Sulem P, Rafnar T, Matullo G, Seminara D, Yoshida T, Saeki N, Andrew AS, Dinney CP, Czerniak B, Zhang ZF, Kiltie AE, Bishop DT, Vineis P, Porru S, Buntinx F, Kellen E, Zeegers MP, Kumar R, Rudnai P, Gurzau E, Koppova K, Mayordomo JI, Sanchez M, Saez B, Lindblom A, de Verdier P, Steineck G, Mills GB, Schned A, Guarrera S, Polidoro S, Chang SC, Lin J, Chang DW, Hale KS, Majewski T, Grossman HB, Thorlacius S, Thorsteinsdottir U, Aben KK, Witjes JA, Stefansson K, Amos CI, Karagas MR, Gu J. Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet 41(9):991-5, 9/2009. PMCID: PMC3313685.

                                          l  Hildebrandt MA, Yang H, Hung MC, Izzo JG, Huang M, Lin J, Ajani JA, Wu X. Genetic Variations in the PI3K/PTEN/AKT/mTOR Pathway are Associated with Clinical Outcomes in Esophageal Cancer Patients Treated with Chemoradiotherapy. J Clin Oncol 27(6):857-71, 2/2009. e-Pub 1/2009. PMCID: PMC2738430.

                                          l  Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X, Vijayakrishnan J, Sullivan K, Matakidou A, Wang Y, Mills G, Doheny K, Tsai YY, Chen WV, Shete S, Spitz MR, Houlston RS. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet 40(5):616-22, 5/2008. e-Pub 4/2008. PMCID: PMC2713680.

                                          l  Wu X, Gu J, Wu TT, Swisher SG, Liao Z, Correa AM, Liu J, Etzel CJ, Amos CI, Huang M, Chiang SS, Milas L, Hittelman WN, Ajani JA. Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer. J Clin Oncol 24(23): 3789-98,2006. PMID: 16785472.

                                          l  Rebbeck TR, Spitz M, Wu X. Assessing the function of genetic variants in candidate gene association studies. Nat Rev Genet 5(8):589-97, 2004. PMID: 15266341.

                                          l  Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, Shay JW, Luo S, Hong WK, Spitz MR. Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst 95(16):1211-8, 2003. PMID: 12928346.

                                          利用高端的生物信息和生物統計方法建立整合性的風險預測模型並轉成一系列個人預測模型的人工智能工具

                                          l  Wu X, Ye Y, Barcenas CH, Chow WH, Meng QH, Chavez-MacGregor M, Hildebrandt MA, Zhao H, Gu X, Deng Y, Wagar E, Esteva FJ, Tripathy D, Hortobagyi GN. Personalized Prognostic Prediction Models for Breast Cancer Recurrence and Survival Incorporating Multidimensional Data. J Natl Cancer Inst 109(7), 7/2017. PMID: 28376179.

                                          l  Wu X, Wen CP, Ye Y, Tsai M, Wen C, Roth JA, Pu X, Chow WH, Huff C, Cunningham S, Huang M, Wu S, Tsao CK, Gu J, Lippman SM. Personalized Risk Assessment in Never, Light, and Heavy Smokers in a prospective cohort in Taiwan. Sci Rep 6:36482, 11/2016. PMCID: PMC5090352.

                                          l  Wen CP, Lin J, Yang YC, Tsai MK, Tsao CK, Etzel C, Huang M, Hsu CY, Ye Y, Mishra L, Hawk E, Wu X. Hepatocellular Carcinoma Risk Prediction Model for the General Population: The Predictive Power of Transaminases. J Natl Cancer Inst 104(20):1599-611, 10/2012. PMCID: PMC3692381.

                                          l  Wu X, Lin J, Grossman HB, Huang M, Gu J, Etzel CJ, Amos CI, Dinney CP, Spitz MR. Projecting Individualized Probabilities of Developing Bladder Cancer in Caucasians. J Clin Oncol 25(31):4974-81, 11/2007. PMID: 17971596.

                                           

                                          教學與人才培養

                                          教學工作

                                          分子流行病學

                                          腫瘤流行病學

                                           

                                          研究生培養

                                          UTHSC-SPH, Jegnish Shah, M.P.H. student, 9/1996-5/1997

                                          UTHSC-SPH, Yan Wen Li, M.D, M.P.H. student, 9/1996-5/1997

                                          UTHSC-SPH, Kei Shi, M.S. student, 1/1997-5/2000

                                          UTHSC-SPH, Yan Wen Li, Graduate Student, 1997

                                          UTHSC-SPH, Huai Lin, Ph.D. student, 9/1997-8/1998

                                          UTHSC-SPH, Matthew B. Schabath, M.S. student, 1/1998-8/2000

                                          UTHSC-SPH, Nimisha Makan, M.S. student, 1/1998-8/2000

                                          UTHSC-SPH, Hua Zhao, M.S. student, 5/1999-9/2000

                                          UTHSC-SPH, Qi Wei, M.P.H. student, 8/1999-7/2000

                                          UTHSC-SPH, Darinka Perisic, M.D., M.P.H. student, 7/2000-5/2001

                                          UTHSC-SPH, Matthew B. Schabath, Ph.D. student, 8/2000-12/2003

                                          UTHSC-GSBS, Aditi Hazra, Ph.D. student, 8/2000-12/2004

                                          UTHSC-SPH, Hua Zhao, Ph.D. student, 9/2000-8/2003

                                          UTHSC-SPH, Edith Napoleon, M.P.H. student, 9/2002-5/2004

                                          UTHSC-SPH, Khan Owis, M.P.H. student, 10/2003-8/2004

                                          UTHSC-SPH, Nancy Tang, Ph.D. student, 3/2004-5/2008

                                          UTHSC-GSBS, Maosheng Huang, Ph.D. student, 3/2004-8/2008

                                          NCI R25T Predoc Fellowship in Cancer Prevention Program, Yale University, School of Public Health, Jessica Clague, M.P.H. student, 5/2005-8/2005

                                          UTHSC-SPH, Manisha Jhamb, M.P.H. student, 8/2005-5/2006

                                          UTHSC-GSBS, Meng Chen, Ph.D. student, 5/2006-8/2009

                                          UTHSC-GSBS, Xia Pu, Ph.D. student, 7/2007-8/2012

                                          UTHSC-GSBS, Jessica Clague, Ph.D. student, 8/2007-8/2009

                                          NCI R25T Predoc Fellowship in Cancer Prevention Program, Yale University, School of Public Health, Samira Kamrudin, M.P.H. student, 5/2008-8/2008

                                          UTHSC-GSBS, Shanyu Zhang, Ph.D. student, 1/2009-8/2009

                                          China, JingYao Dai, Visiting Ph.D. student, 2010-2011

                                          UTHSC-GSBS, Sarah Tambra, M.S. Student, 6/2010-5/2011

                                          UTHSC-SPH, Jeanne Pierzynski, M.P.H Student, 6/2010-5/2012

                                          UTHSC-SPH, Xiang Shu, Ph.D. Student, 9/2010-present

                                          UTHSC-GSBS, Fanmao Zhang, Ph.D. Student, 1/2011-8/2014

                                          UTHSC-GSBS, Lixia Han, Ph.D. Student, 3/2013-5/2015

                                          UTHSC-GSBS, Shu-Hong Lin, Ph.D. Student, 3/2013-5/2018

                                          UTHSC-GSBS, Jeanne Pierzynski, Ph.D. Student, 8/2013-12/2017

                                          Kunlin Xie, Visiting Ph.D. Student, 3/2016-6/2018

                                          Yanwei Zhang, Visiting Ph.D. Student, 9/2014-6/2015

                                          UTHSC-SPH, Fang Yu Lin, Ph.D. Student, 12/2014-present

                                           

                                          博士後培養

                                          Dr. Juehui Liu, 11/1995-11/1996

                                          Dr. Min Wang, 11/1997-2/1999

                                          Dr. Yaohua Hu, 1/1998-10/1998

                                          Dr. Huifeng Zhang, 11/1998-6/2004

                                          Dr. Yunfei Wang, 12/1999-6/2004

                                          Dr. Yong Zhu, 5/2000-12/2002

                                          Dr. Kerang Zhang, 6/2000-5/2002

                                          Dr. Seun-Ja Park, 7/2001-12/2001

                                          Dr. Lina Shao, 7/2002-6/2005

                                          Dr. Jie Lin, 1/2003-9/2005

                                          Dr. Hua Zhao, 9/2003-10/2004

                                          Dr. Matthew Schabath, 1/2004-8/2006

                                          Dr. Hushan Yang, 6/2005-7/2009

                                          Dr. Yuanqing Ye, 7/2006-5/2008

                                          Dr. Michelle Hildebrandt, 7/2007-12/2009

                                          Dr. Adrian Cassidy, 9/2007-10/2008

                                          Dr. Xiaofan Zhang, 9/2008-9/2011

                                          Dr. YiLei Gong, 2/2009-5/2011

                                          Dr. Hua Wei, 2/2009-present

                                          Dr. Meng Chen, 9/2009-8/2012

                                          Dr. Hung-Lung Ke, 1/2010-2011

                                          Dr. Yan Wang, 4/2010-4/2013

                                          Dr. Wenjie Sun, 7/2011-7/2013

                                          Dr. Jie Lian, 12/2011-12/2014

                                          Dr. Beatriz Sánchez-Espiridión, 6/2012-2/2016

                                          Dr. Anthony D'Amelio, 8/2012-12/2012

                                          Dr. Xia Pu, 9/2012-8/2014

                                          Dr. Xin Wang, 2/2013-4/2014

                                          Dr. Stephanie Melkonian, 7/2013-9/2015

                                          Dr. Huakang Tu, 7/2014-12/2018

                                          Dr. Liren Zhang, 2/2015-12/2017

                                          Dr. Hao Yu, 8/2015-10/2017

                                          Dr. Yajie Zhang, Ph.D., 11/2017-10/2018

                                           

                                          臨牀人才培養

                                          Dr. Yanwen Li, NIOSH Fellow, 4/1996-9/1997

                                          Dr. Tianying Yuan, NIOSH Fellow, 10/1996-5/1997

                                          Dr. Lie Chen, NIOSH Fellow, 9/1997-10/1997

                                          Dr. Dan Leibovici, Urology Oncology Fellow, 7/2003-6/2005

                                          Dr. Salvador Saldivar, Gynecology Oncology Fellow, 7/2003-4/2006

                                          Dr. Yimin Zhu, Visiting Scientist, 4/2005-6/2007

                                          Dr. Jinliang Xing, Visiting Scientist, 4/2005-2/2008

                                          Dr. Karim Kader, Urology Oncology Fellow, 7/2005-6/2007

                                          Dr. Wei Wang, Visiting Scientist, 9/2005-5/2008

                                          Dr. Yohei Horikawa, Visiting Scientist, 6/2006-5/2008

                                          Dr. Angela Coscio, Hematology and Oncology Fellow, 9/2008-8/2010

                                          Dr. Larissa Alejandra Meyer, Gynecologic Oncology Fellow, 10/2008-8/2011

                                          Dr. Weiqi Tan, Visiting Scientist, 2/2009-11/2010

                                          Dr. Jian-Ming Wang, Visiting Scientist, 5/2009-4/2010

                                          Dr. Jikai Yin, Visiting Scientist, 5/2009-5/2011

                                          Dr. Moubin Lin, Visiting Scientist, 6/2009-3/2011

                                          Dr. Eric Kim, Hematology and Oncology Fellow, 1/2010-6/2012

                                          Dr. Klaus Wagner, Hematology and Oncology Fellow, 2010-2013

                                          Dr. Da-Tien Bau, Sister Institution Associate, 8/2010-2/2011

                                          Dr. Yonggang He, Visiting Scientist, 4/2011-2014

                                          Dr. Enping Xu, Visiting Scientist, 6/2011-6/2013

                                          Dr. Saad Aldousari, Urology Oncology Fellow, 7/2011-2013

                                          Dr. Hui Xie, Visiting Scientist, 12/2011-12/2012

                                          Dr. Mario Fernandez, 1/2012-12/2012

                                          Dr. Yuhui Sun, Visiting Scientist, 5/2013-5/2014

                                          Dr. Rosalinda Mendoza, Visiting Scientist, 11/2013-4/2015

                                          Dr. Rong Li, Visiting Scientist, 12/2013-3/2015

                                          Dr. Julia Mendoza, Visiting Scientist, 12/2013-present

                                          Dr. Lina Zhao, Visiting Scientist, 1/2014-2/2015

                                          Dr. Xiaoan Liu, Visiting Scientist, 3/2014-9/2014

                                          Dr. Stephen Williams, Urology Fellow, 4/2014-6/2016

                                          MD Anderson Cancer Center, Dr. Li Zhang, Visiting Scientist, 5/2014-10/2014

                                          MD Anderson Cancer Center, Dr. Wenquan Niu, Visiting Scientist, 6/2014-6/2015

                                          Dr. Miguel Santibanez, Visiting Scientist, 12/2014-4/2015

                                          MD Anderson Cancer Center, Dr. Yuan Mao, Visiting Scientist, 12/2014-6/2015

                                          Dr. Yang Deng, Visiting Scientist, 5/2015-10/2016

                                          Dr. Jianchun Gu, Visiting Scientist, 8/2015-10/2016

                                          Dr. Qinchuan Wang, Visiting Scientist, 11/2015-10/2017

                                          Dr. Jingfen Zhu, Visiting Scientist, 12/2015-12/2016

                                          Dr. Meiling Zhu, Visiting Scientist, 12/2016-9/2018

                                           

                                          其他人員培養

                                          Mentor, Pooja Rohatgi, Baylor College of Medicine, 8/2005-5/2006

                                          Mentor, Amy Tsou, High School Student, 2000

                                          Mentor, Carla Blieden, College Program, 2000

                                          Mentor, Leah Yieh, High School Student, 2002

                                          Mentor, Mauricio Smart, College Program, 2004

                                          Mentor, Yubo Gong, College Student, 2004

                                          Mentor, Albert Ramirez, High School Student, 2005

                                          Mentor, Hek Kevon Matdoost, College Student, 2005

                                          Mentor, Joshua Chang, College Student, 2008-2011

                                          Mentor, Yiyang Wu, High School student, 2008

                                          Mentor, Luther Fan, High School student, 2009-2010

                                          Mentor, Alice Jiang, High School student, 2009

                                          Mentor, Cancer Prevention Research Training Program, Sonny Nguyen, College Student, 6/2012-8/2012

                                          Mentor, Emily Wu, College Student, 7/2012-8/2012

                                          Mentor, Tristan Lim, High School Student, 7/2012-8/2012

                                          Mentor, Non-Competitive (Track 2) MD Anderson Summer Experience, Jaclyn Ly, Graduate Student, 6/2013-8/2013

                                          Mentor, Tristan Lim, High School Student, 7/2014-8/2014

                                          Mentor, MD Anderson Cancer Center, Jeremy Mani, College Student, 6/2015-7/2015

                                          Mentor, MD Anderson Cancer Center, Gabriela Mata, High School Student, 6/2015-8/2015

                                          Mentor, MD Anderson Cancer Center, Kierra Morris, High School Student, 6/2015-8/2015

                                          Mentor, MD Anderson Cancer Center, Molly Lu, High School Student, 6/2015-8/2015

                                           

                                          研究生學術委員會

                                          Advisor, UTSPH, Gladstone Airewele, M.P.H. Advisory Committee, 9/1996-8/1998

                                          Advisor, UTSPH, Karen Joanne Wiley, M.S. Advisory Committee, 1/1997-8/1998

                                          Member, UTSPH, Joseph Anthony Trachier, M.P.H. Advisory Committee, 1/1997-9/2000

                                          Member, UTSPH, Suzanne E. Hegemier, M.P.H. Advisory Committee, 1/1997-9/2000

                                          Member, UTSPH, Lixing Zhang, Ph.D. Advisory Committee, 1/1997-12/2000

                                          Member, UTSPH, Janice Marie Beal, M.P.H. Advisory Committee, 10/1997-9/2000

                                          Advisor, UTSPH, Rosalyn B. Beaty, M.P.H. Advisory Committee, 1/1998-5/2000

                                          Member, UTSPH, Francine Kay Kingston, M.P.H. Advisory Committee, 1/1999-5/2000

                                          Member, UTSPH, Chris Henry Ojeih, M.P.H. Advisory Committee, 1/1999-9/2000

                                          Advisor, UTSPH, Joseph Roth, M.S. Advisory Committee, 8/1999-9/2000

                                          Advisor, UTSPH, Lisa Kennedy, M.S. Advisory Committee, 8/1999-9/2000

                                           

                                          培養的人才所獲獎項

                                          1.     Matthew Schabath, AACR Scholar-in-Training Award, 2002

                                          2.     Yong Zhu, 1st Place, MDACC Trainee Recognition Day, 2002

                                          3.     Yong Zhu, AACR Scholar-in-Training Award, 2002

                                          4.     Matthew Schabath, MDACC Trainee Recognition Award, 2003

                                          5.     Matthew Schabath, AACR Scholar-in-Training Award, 2003

                                          6.     Aditi Hazra, Andrew Sowell-Wade Huggins Scholar Award, 2003

                                          7.     Matthew Schabath, AACR Scholar-in-Training Award, 2005

                                          8.     Matthew Schabath, AACR Scholar-in-Training Award, 2006 

                                          9.     Maosheng Huang, AACR Scholar-in-Training Award, 2006 

                                          10.  Yuanqing Ye, Poster Winner, MDACC Trainee Recognition Day, 2007 

                                          11.  Matthew Schabath, Benard Levin 1st Place Poster Award, 2007 

                                          12.  Maosheng Huang, AACR Scholar-in-Training Award, 2007

                                          13.  Yuanqing Ye, AACR Scholar-in-Training Award, 2007 

                                          14.  Hushan Yang, 1st Place, MDACC Trainee Recognition Day, 2007 

                                          15.  Meng Chen, International Society of Gastrointestinal Oncology-Trainee Award, 2007 

                                          16.  Jinliang Xing, International Society of Gastrointestinal Oncology-Trainee Award, 2007 

                                          17.  Jessica Clague, Graduate Student Poster Award, Trainee Recognition Day, 2008 

                                          18.  Michelle HIldebrandt, Postgraduate Poster Award, Trainee Recognition Day, 2008 

                                          19.  Hushan Yang, 2nd Place, MDACC Trainee Recognition Day, 2008 

                                          20.  Meng Chen, AACR Frontiers on Cancer Prevention Research Trainee Award, 2008 

                                          21.  Jessica Clague, Division of Cnacer Prevention Trainee Award, 2008 

                                          22.  Jessica Clague, AACR Frontiers on Cancer Prevention Scholar-in-Training, 2008

                                          23.  Xia Pu, AACR Scholar-in-Training Award 2009 

                                          24.  Xia Pu, 2nd Place, MDACC Trainee Recongnition Day, 2009 

                                          25.  Meng Chen, AACR Scholar-in-Training Award, 2009 

                                          26.  Hushan Yang, AACR Scholar-in-Training Award, 2009 

                                          27.  Michelle Hildebrandt, MDACC Trainee of the Quarter, 2009 

                                          28.  Michelle Hildebrandt, MDACC Trainee Excellence Award, 2009 

                                          29.  Michelle HIldebrandt, AACR Frontiers in Cancer Prevention Scholar-in-Training Award, 2009 

                                          30.  Klaus Wagner, ASCO Clinical Fellow Merit Award, 2010 

                                          31.  Eric Kim, ASCO Clinical Fellow Merit Award, 2010 

                                          32.  Meng Chen, AACR Scholar-in-Training Award, 2010 

                                          33.  Klaus Wagner, MDACC Trainee Excellence Award, 2010 

                                          34.  Eric Kim, AACR GlaxoSmithKline Clinical Cancer Research Scholar Award, 2011

                                          35.  Xia Pu, AACR Scholar-in-Training Award, 2011

                                          36.  Xia Pu, AACR Scholar-in-Training Award, 2012

                                          37.  Xia Pu, AACR Scholar-in-Training Award, 2013

                                          38.  Fanmao Zhang, MD Anderson Trainee Excellence Award, 2013 

                                          39.  Shu-Hong Lin, MD Anderson Trainee Research Day - Oral Competition, 1st Place (Grad/Undergrad) -  Clinical Research, 2014

                                          40.  Xia Pu, MD Anderson Trainee Research Day - Poster Competition, 1st Place (Postdoc/Clinical Fellows) -Population Science, 2014

                                          41.  Jeanne Pierzynski, MD Anderson Trainee Research Day - Poster Competition, 1st Place (Grad/Undergrad) - Population Science, 2014

                                          42.  Stephanie Melkonian, MD Anderson Trainee Research Day - Oral Competition Finalist, (Postdoc/Clinical Fellows) - Population Science, 2014

                                          43.  Fanmao Zhang, MD Anderson Trainee Research Day - Oral Competition Finalist (Grad/Undergrad) - Population Science, 2014

                                          44.  Beatriz Sanchez Espiridion, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical Fellows) - Population Science, 2014

                                          45.  Jie Lian, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical Fellows) - Population Science, 2014

                                          46.  Xin Wang, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical            Fellows) - Population Science, 2014

                                          47.  Lixia Han, MD Anderson Trainee Research Day - Poster Competition Finalist (Grad/Undergrad) -             Population Science, 2014

                                          48.  Jeanne Pierzynski - Predoctoral R25T Cancer Prevention Fellowship Award, April 2014 

                                          49.  Stephanie Melkonian - MD Anderson Trainee Research Day - Oral Competition, 1st Place (Postdoc/Clinical Fellows) - Population Science, 2015 

                                          50.  Beatriz Sanchez Espiridion, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical Fellows) - Population Science, 2015

                                          51.  Huakang Tu, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical Fellows) - Population Science, 2015 

                                          52.  Jeanne Pierzynski, MD Anderson Trainee Research Day - Poster Competition, 1st Place (Grad/Undergrad) - Population Science, 2015 

                                          53.  Stephen Williams, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical Fellows) - Basic Sciences, 2015

                                          54.  Xiang Shu, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical Fellows) - Translational Research, 2015

                                          55.  Stephen Williams, Comparative Effectiveness Resarch on Cancer in Texas (CERCIT) Scholar, 2015

                                          56.  Stephen Williams, Conquer Cancer Foundation, American Society of Clinical Oncology Merit Award, 2015

                                          57.  Stephen Williams, Société Internationale d'Urologie (SIU) United States National Chapter, Traveling Scholarship Award, 2015

                                          58.  Liren Zhang, AACR Scholar-in-Training Award, 2016

                                          59.  Jeanne Pierzynski, AACR Scholar-in-Training Award, 2016

                                          60.  Huakang Tu, Ph.D., - MD Anderson Trainee Research Day - Oral Oral Competition, 1st Place (Postdoc/Clinical Fellows) - Population Science, 2017

                                          61.  Huakang Tu, Ph.D., - MD Anderson Trainee Research Day - Oral Oral Competition, 1st Place (Postdoc/Clinical Fellows) - Clinical Research, 2018 

                                           

                                          學術兼職

                                          l  美國國家衛生研究院, Cancer Genetics Study Section, 課題評審委員會專家(2013-2019)

                                          l  美國國防部科研基金, Lung Cancer Research Program Concept Award ,評審專家(2011-2017)

                                          l  歐盟研究基金會, ERC Starting Grants Panel, Genetic, Genomics, Bioinformatics and Systems Biology, 課題評審委員會專家(2015-至今)

                                          l  英國癌症研究基金,Population Research Committee ,課題評審委員會專家(2015-至今)

                                          l  美國國家衛生研究院 P01 重大項目基金 ,評審委員會專家(2004、2005、2007、2009、2010、2011、2012、2013、2014、2016、2017)

                                          l  美國國家衛生研究院 ,Special Emphasis Panel (SEP) - Loan Repayment Program ,課題評審委員會專家(2010、2011、2012、2013、2014、2015、2016)

                                          l  國際膀胱癌協會聯合創始人 ,協調委員會主席(2011-2017)

                                          l  美國癌症研究學會(AACR)癌症流行病學和預防會議學術獎評比委員會委員(2014-2016)

                                          l  中國國家分子醫學轉化科學中心顧問委員會委員(2015-2018)

                                          l  美國癌症協會(ACS),Clinical Cancer Research and Epidemiology (CCE),課題評審委員會專家(2008-2013)

                                          l  美國國家衛生研究院, NCI Intramural Program,評審專家(2010、2013)

                                          l  美國國家衛生研究院 ,Epidemiology of Cancer Study Section (EPIC),課題評審委員會專家(2004,2005-2009 , 2010)

                                          l  美國國家衛生研究院, Small Grant for Cancer Research and Cancer Epidemiology Study Section,課題評審委員會專家(2005-2006)

                                          l  美國國家癌症研究中心PREPAC項目專家顧問委員會成員(2006-2011)

                                          l  美國癌症研究中心上海女性健康研究隊列特邀顧問(2013-2017)

                                          l  AACR年會流行病組科學評審委員會共同主席(2012)

                                          l  AACR癌症預防研究進展年會科學評審委員會共同主席(2012)

                                          l  Landon-AACR國際創新獎評審委員會委員(2009-2010)

                                          l  波蘭國家科學中心, 課題評審委員會專家(2015)

                                          l  美國國家癌症研究中心, Outstanding Investigator Award Initiative,評審委員會專家(2015)

                                          l  香港衛生署 ,課題評審專家(2009、2010、2014、2015、2016)

                                          l  美國癌症研究所(AICR), 課題評審專家(2014)

                                          l  英國Wellcome Trust基金,課題評審專家(2006, 2014)

                                          l  西班牙加泰羅尼亞健康信息評估中心,課題評審專家(2013)

                                          l  法國國家生命和健康科學聯盟 ,課題評審專家(2013)

                                          l  世界癌症研究基金會, 課題評審專家(2013)

                                          l  英國癌症研究基金,Science Funding Review Panel/Programme Grant Review,課題評審委員會專家(2006-2009, 2009-現在)

                                          l  美國癌症研究學會,Innovator Award for International Collaboration in Cancer Research,評審委員會專家(2012)

                                          l  卡塔爾國家科研基金會,課題評審專家(2010)

                                          l  新加坡國家醫學研究資助委員會,課題評審專家(2010)

                                          l  荷蘭癌症協會,課題評審專家(2010)

                                          l  意大利Istituto Toscano Tumori基金,課題評審專家(2009-2015)

                                          l  美國國家衛生研究院, GGG Shared Instrumentation,課題評委員會審專家(2009)

                                          l  美國國家衛生研究院 ,Transdisciplinary Research on Energetics and Cancer (TREC) and TREC Coordinating Centers Study Section, 課題評審委員會專家(2005)

                                          l  Cancer Research雜誌常務編委(2008-2012)

                                          l  近50家知名雜誌審稿人,包括New England Journal of Medicine, Lancet, JAMA, Nature Genetics, Journal of Clinical Oncology, Journal of the National Cancer Institute等


                                          獎勵及榮譽

                                          2016年 ,獲腫瘤預防傑出導師獎,MD安德森癌症中心

                                          2015年,獲國際結直腸癌多學科診治會議傑出貢獻獎

                                          2014年 ,獲休斯頓市50位最具影響力女性獎

                                          2012,2011 ,2010,2009 ,2008,2007年,獲卓越的領導和支持導師證書

                                          2011年 ,獲Robert M. Chamberlain 傑出導師獎,MD安德森癌症中心

                                          2010年,獲腫瘤預防傑出導師獎,MD安德森癌症中心

                                          2008年,獲Margaret and James A. Elkins, Jr.腫瘤預防傑出成就獎,MD安德森癌症中心

                                          2008年,獲Julie and Ben Rogers基礎科研成就獎 ,MD安德森癌症中心

                                          2008年 ,獲MD安德森基金資深院士. 這一稱號可獲175萬美元資助 。MD安德森有6位獲這稱號

                                          2008年,授予癌症預防Betty B. Marcus冠名主席

                                          2007年 ,獲最佳老闆入圍獎

                                          2006年,授予Ashbel Smith冠名教授

                                          2002年 ,獲傑出學者獎,MD安德森癌症中心