||Biology of pathogens
||Faculty of Basic Medicine
||pathogenesis of respiratory bacterial pathogens, especially Mycobacterium tuberculosis
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Dr. Zhe Zhang is the Associate professor at the department of microbiology and parasitology, Zhejiang University School of Medicine. She is also a scientific researcher at the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. Her research interest is the pathogenesis of respiratory bacterial pathogens, especially Mycobacterium tuberculosis.
She obtained her B.S. degree from the department of microbiology at Shandong University in 1996. She received her doctorate degree from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences in 2001. Her Ph.D. thesis work was focused on signal transduction mediated by cellular transmembrane receptors. Academician of the Chinese Academy of Sciences Gang Pei was her mentor. From 2001 to 2009, she worked as a postdoctoral researcher and then research associate at the University of Pennsylvania School of medicine in the USA on molecular mechanisms of respiratory infections diseases, and was involved in the NIH project mechanisms of pneumococcal persistence during carriage (5R01AI038446）led by Professor Jeffrey N. Weiser at the department of microbiology.
In Sept. 2010, she joined Zhejiang University School of medicine as a faculty, and has been actively involved in teaching and basic medical research. She is taking part in a National key Project of Science and Technology led by the academician of Chinese Academy of Engeneering Lanjuan Li titled large scale on-site epidemiology and intervention research on AIDS, viral hepatitis and tuberculosis in Zhejiang province (2009ZX10004-901), and is supervising a sub-project titled study of mechanisms and epidemiology of anti-drug resistance effect of tetrandrine using MTB strains from community tuberculosis patients. Another project led by her on the molecular and cellular basis underlying the interactions between vaccine Bacillus Calmette-Guérin (BCG) and the host in the induction of protection against Mycobacterium tuberculosis has been founded by Ministry of Finance and Ministry of Education. By far she has published over 11 research articles which have received a total citation of over 380 times. One of her research paper titled cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice was published in 2009 in Journal of Clinical Investigation (IF=16.799). Her research has also been reported on international conferences many times.