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                                                                          钱柜平台

                                                                          移動站  | 2019年04月28日 星期日
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                                                                          基本信息:

                                                                          姓名: 單鵬飛
                                                                          職務: 浙醫二院科教部副主任
                                                                          職稱: 主任醫師
                                                                          學歷: 博士
                                                                          專業: 內分泌代謝病學
                                                                          所屬院系: 浙醫二院
                                                                          研究方向: 糖尿病 動脈鈣化 鈣磷代謝
                                                                          電話: 87784623
                                                                          信箱: pengfeishan@zju.edu.cn
                                                                          個人主頁:

                                                                          個人簡介:

                                                                          博士,钱柜平台附屬第二醫院主任醫師。畢業於湘雅钱柜平台 ,分別獲學士、碩士和博士學位 ,哈佛大學钱柜平台Joslin糖尿病中心留學專家 。浙江省醫學會內分泌學分會中青年副主任委員 ,中華醫學會骨質疏鬆和骨礦鹽疾病分會社區與基層工作學組委員,浙江省醫學會營養學分會慢病管理學組委員,省醫師協會專家志願者 ,SCI雜誌International Journal of Endocrinology的Lead Guest Editor ,SCI雜誌審稿專家 ,國家自然科學基金一審專家 ,中華內分泌代謝雜誌特邀審稿專家。主持國家自然科學基金4項 。擅長糖尿病、肥胖、代謝綜合徵、骨質疏鬆、垂體、甲狀腺疾病等內分泌疾病的臨牀診治 。致力於糖尿病綜合治療和減藥停藥的研究 。

                                                                          近年的主要研究項目

                                                                           

                                                                          1. 國家自然科學基金面上項目:項目編號81870564 ,OPG/RANKL/RANK系統調控血管新生改善糖尿病小鼠下肢股動脈缺血損傷及機制研究 , 2019/01-2022/12,直接經費57萬元,主持。

                                                                          2. 國家自然科學基金面上項目 ,81670744 ,血漿激肽釋放酶酶切NMDA受體1促進糖尿病視網膜神經損傷及其機制研究 ,2017/01-2020/12 ,總經費69.6萬 ,主持 。

                                                                          3. 國家自然科學基金面上項目 ,81370968 ,Apelin/APJ 系統調控動脈鈣化的模式和機制研究,2014/01-2017/12,80萬,主持 。

                                                                          4. 國家自然科學基金面上項目,Annexin A2糖基化在高血糖加重缺血性腦損傷中的作 用及機制研究,2011 /01-2014/12  ,67萬 ,參加。

                                                                          5. 國家自然科學基金項目 ,30801203 , 護骨素調控血管平滑肌細胞向成骨細胞分化 對動脈鈣化的影響及機理研究,2009/01-2011/12 ,20萬 ,主持  。

                                                                          6. 浙江省衛生廳優秀人才基金 ,2009QN012 ,核因子-κB活化因子配體抑制劑(Denos umab)干預LDLR(-/-)小鼠動脈鈣化和動脈粥樣硬化的研究 ;2009/6-2011/6  ,3萬,主持 。



                                                                          參編的主要著作:

                                                                          譯著《全科醫學臨牀住院醫師指導手冊》,2017 ,人民衛生出版社 , Mori J. Morikawa主編 ;

                                                                          《臨牀甲狀腺病學》  ,2013,人民衛生出版社,向光大主編 ;

                                                                          《內分泌學》第3版 ,2012  ,人民衛生出版社 ,廖二元主編;

                                                                          《內分泌學》第2版 ,2007 ,人民衛生出版社,廖二元主編 ;

                                                                          《內分泌學手冊》  ,2006 ,人民衛生出版社,廖二元主編 ;

                                                                          《代謝性骨病學》,2003,人民衛生出版社 ,廖二元主編  ;

                                                                          《激素敏感綜合徵和激素不敏感綜合徵》,2002 ,人民衛生出版社,廖二元主編)  。

                                                                          發表的主要學術論文:

                                                                          1. Wu Y, He J, Sun X, Zhao YM, Lou HY, Ji XL, Pang XH, Shan LZ, Kang YX, Xu J, Zhang SZ, Wang YJ, Ren YZ, Shan PF*. Carotid atherosclerosis and its relationship to coronary heart disease and stroke risk in patients with type 2 diabetes mellitus, Medicine (Baltimore), 2017, 96(39):e8151.(通訊作者)

                                                                          2. Pang XH, Han J, Ye WL, Sun X, Ding Y, Huang WJ, Zhao YM, Lou HY, Shan LZ, Kang YX, Song XX, Zhang SZ, Gu W, Shan PF*. Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China. Int J Endocrinol, 2017, 2017:9620513. (通訊作者)

                                                                          3. Shan PF*, Li Q, Khamaisi M, Qiang GF. Type 2 Diabetes Mellitus and Macrovascular Complications. Int J Endocrinol, 2017;2017:4301461. (通訊作者)

                                                                          4. Ding Y, Sun X, Shan PF. MicroRNAs and Cardiovascular Disease in Diabetes Mellitus. Biomed Res Int. 2017;2017:4080364. (通訊作者)

                                                                          5. Sun X, He J, Ji XL, Zhao YM, Lou HY, Song XX, Shan LZ, Kang YX, Zeng WH, Pang XH, Zhang SZ, Ding Y, Ren YZ, Shan PF*. Association of Chronic Kidney Disease with Coronary Heart Disease and Stroke Risks in Paents with Type 2 Diabetes Mellitus: An Observational Cross-sectional Study in Hangzhou, China. Chin Med J (Engl). 2017 5th Jan 2017;130(1):57-63. (通訊作者)

                                                                          6. Sun X, Shan PF, Ding Y, Yu H, Song ZY. Comment on Gagnum et al. Long-term Mortality and End-Stage Renal Disease in a Type 1 Diabetes Population Diagnosed at Age 15-29 Years in Norway. Diabetes Care 2017;40:38-45. Diabetes Care. 2017 Sep;40(9):e124.

                                                                          7. Yao MF, He J, Sun X, Ji XL, Ding Y, Zhao YM, Lou HY, Song XX, Shan LZ, Kang YX, Zhang SZ, Shan PF*. Gender Differences in Risks of Coronary Heart Disease and Stroke in Patients with Type 2 Diabetes Mellitus and Their Association with Metabolic Syndrome in China. Int J Endocrinol. 2016;2016:8483405. (通訊作者)

                                                                          8. Shan PF, Ji XL, Wang L, Li P, Ren YZ. Comment on Tang et al. Effects of Insulin Glargine and Liraglutide Therapy on Liver Fat as Measured by Magnetic Resonance in Patients With Type 2 Diabetes: A Randomized Trial. Diabetes Care 2015;38:1339-1346. Diabetes Care. 2015 Sep;38(9):e148–9.

                                                                          9. Yuan LQ, Ouyang HW, Andersen TL, Jiang Y, Pantano F, Shan PF. Osteoporosis 2014. Int J Endocrinol. 2015; 2015:567593.

                                                                          10. Shan PF, Ji XL. Comment on Lin et al. Risk Factors for Decline in IQ in Youth With Type 1 Diabetes Over the 12 Years From Diagnosis/Illness Onset. Diabetes Care 2015;38:236-242. Diabetes Care. 2015 Aug;38(8):e120.

                                                                          11. Zou QL, Wei GN, Chen JX, Ye Q,  Shan PF*.Hepatitis B virus-associated nephropathy in a patient with diabetes mellitus. J Diabetes Investig 2014;5(1):87–89. (通訊作者)

                                                                          12. Zheng J, Shan PF, Gu W. The efficacy of metformin in pregnant women with polycystic ovary syndrome: a meta-analysis of clinical trials. J Endocrinol Invest 2013;36(10):797802.(共同第一作者)

                                                                          13. Zhu X, Jiang Y, Shan PF, Shen J, Liang QH, Cui RR, Liu Y, Liu GY, Wu SS, Lu Q, Xie H, Liu YS, Yuan LQ, Liao EY. Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway. Amino Acids, 44(3):961–968, 2013.

                                                                          14. Shan PF, Xian CJ, Li M, Xiang GD, Yuan LQ. Osteoporosis. Int J Endocrinol. 2013;2013:952858.

                                                                          15. Yin JH, Song ZY, Shan PF*, Xu J, Ye ZM, Xu XH, Zhang SZ, Liang Q, Zhao Y, Ren Z, Yu YP. Age- and gender-specific prevalence of carotid atherosclerosis and its association with metabolic syndrome in Hangzhou, China. Clin Endocrinol (Oxf), 76(6):802–809, 2012

                                                                          (通訊作者)

                                                                          16. Shan PF, Lu Y, Cui RR, Jiang Y, Yuan LQ, Liao EY. Apelin Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells. PLoS One 2011, 6(3):e17938.

                                                                          17. Shan PF, Wu XP, Zhang H, Cao XZ, Yuan LQ, Liao EY. Age-related bone mineral density, osteoporosis rate and risk of vertebral fracture in mainland Chinese women with type 2 diabetes mellitus. J Endocrinol Invest. 2011 Mar;34(3):190–196.

                                                                          18. Shan PF, Wu XP, Zhang H, Cao XZ, Gu W, Deng XG, Gu C, Liao EY. Bone mineral density and its relationship with Body mass index in postmenopausal women with type 2 diabetes mellitus in mainland China. J Bone Miner Metab 2009, 27:190–197.

                                                                          19. Shan PF, Wu XP, Zhang H, Luo XH, Cao XZ, Xie H, Liu SP, Pi YZ, Fang TY, Liu H, Chen ZH, Zhong N, Liao EY. Age-related changes of serum bone alkaline phosphatase and cross-linked c-telopeptides of type I collagen and the relationship with bone mineral density in Chinese women. Clin Chim Acta, 2006, 366, 233–238.

                                                                          20. Gu W, Zou LX, Shan PF, Chen YD. Analysis of urinary proteomic patterns for diabetic nephropathy by ProteinChip. Protemics Clinical Applications 2008; 2: 744–750.

                                                                          21. Wu XP, Hou YL, Zhang H, Shan PF, Zhao Q, Cao XZ, Dai RC, Luo XH, Liao EY.

                                                                          Establishment of BMD reference databases for the diagnosis and evaluation of osteoporosis in central southern Chinese men. J Bone Miner Metab. 2008;26(6):586-94.

                                                                          22. Tang SY, Shan PF, Xie H, Wu XP, Liao EY, Zhang H. Bone mineral content and bone mineral density at lumbar spine and forearm in Chinese girls aged 6-18 years. J Endocrinol Invest, 2007, 30(3): 205–209.

                                                                          23. Luo XH, Guo LJ, Shan PF, Xie H, Wu XP, Zhang H, Cao XZ, Yuan LQ, Liao EY. Relationship of circulating MMP–2, MMP–1, and TIMP–1 levels with bone biochemical markers and bone mineral density in postmenopausal Chinese women. Osteoporos Int, 2006, 17: 521–526.

                                                                          24. Wu XP, Dai RC, Shan PF, Yuan LQ, Cao XZ, Liao EY, Jiang Y. Establishment of BMD reference curves at different skeletal sites in women, using a Cartesian coordinate numeration system. Osteoporos Int, 2005, 16:1655–1662.

                                                                          25. Guo LJ, Luo XH, Wu XP, Shan PF, Zhang H, Cao XZ, Xie H, Liao EY. Serum concentrations of MMP-1, MMP-2, and TIMP-1 in Chinese women: Age-related changes, and the relationships with bone biochemical markers, bone mineral density. Clin Chim Acta, 2006, 371: 137–142.

                                                                          26. Wu XP, Liao EY, Dai RC, Shan PF, Fang TY, Luo XH, Pi YZ, Jiang Y. Comparison of spine and femur reference data in native Chinese women from different regions of China. Osteoporos Int, 2005, 16:1215–1224.

                                                                          27. Wu XP, Liao EY, Zhang H, Shan PF, Cao XZ, Liu SP. Establishment of BMD reference plots and determination of peak BMD at multiple skeletal regions in mainland Chinese women and the diagnosis of osteoporosis. Osteoporos Int, 2004, 15:71–79.

                                                                          28. Wu XP, Liao EY, Zhang H, Dai RC, Shan PFCao XZ, Liu SP, Jiang Y. Relationship of body surface area with bone density and its risk of osteoporosis at various skeletal regions in women of mainland China. Osteoporos Int, 2004, 15:751–759.

                                                                          29. Wu XP, Liao EY, Zhang H, Dai RC, Shan PF, Cao XZ, Liu SP, Jiang Y. Determination of age-specific bone mineral density and comparison of diagnosis and prevalence of primary osteoporosis in Chinese women based on both Chinese and World Health Organization criteria. J Bone Miner Metab, 2004, 22:382–391.

                                                                          30. Zhong N, Wu XP, Xu ZR, Wang AH, Luo XH, Cao XZ, Xie H, Shan PF, Liao EY. Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. Clin Chim Acta, 2005, 351:161–168.

                                                                          31. 姚美芳 ,孫雪,韓珏 ,屠伊娜 ,何潔,趙一鳴,樓寒鈺,龐曉虹,曾文衡 ,張鬆照,單鵬飛 ,2型糖尿病患者合併代謝綜合徵增加Framingham心血管評分  ,钱柜學報(醫學版) ,2016.5.8  ,45(3)268~274

                                                                          32.單鵬飛,繼發於艾滋病的原發性腎上腺皮質功能減退一例,中華內科雜誌 ,2012 ,516):481-482 。

                                                                          33. 單鵬飛, 谷衛. 肥胖相關性腎損害及其臨牀處理. 實用糖尿病雜, 2007, 3:3–4.

                                                                          34. 單鵬飛, 伍賢平, 張紅, 羅湘杭, 曹行之, 謝輝, 劉石平, 廖二元. 女性護骨素啓動子區209245多態性和骨密度及骨轉換的關係. 中華內分泌代謝雜誌, 2007, 23:228–230.

                                                                          35. 單鵬飛, 伍賢平, 廖二元, 張紅, 羅湘杭, 曹行之, 謝輝, 劉石平. 女性骨代謝轉換生化指標和骨密度隨年齡變化及其相互關係. 中華老年醫學雜誌, 2005, 24:431–434.

                                                                          36. 單鵬飛, 伍賢平, 廖二元, 張紅, 羅湘杭, 曹行之, 謝輝, 劉石平女性甲狀旁腺激素隨年齡變化規律及其與骨密度的關係.中華內科雜誌, 2005, 443:213–214.

                                                                          37. 張紅, 單鵬飛, 羅湘杭, 伍賢平, 廖二元. 長沙市郊區女性骨質疏鬆縱向觀察.中華醫學雜誌2006,86: 2986–2989.

                                                                          38. 劉石平, 廖二元, 伍賢平, 曹行之, 單鵬飛, 蘇欣. 尿Ⅰ型膠原羧基末端肽和氨基末端肽排泄率與年齡、絕經和絕經後骨丟失的關係. 中華醫學雜誌,2006,86: 371–375.

                                                                            39. 張紅, 羅湘杭, 謝輝, 伍賢平, 單鵬飛, 曹行之, 廖二元. 基質金屬蛋白酶-1-2與年齡、骨轉換生化指標及骨密度的關係. 中華內科雜誌, 2006, 45:306–309.