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                                                                          钱柜平台

                                                                          移動站  | 2019年04月28日 星期日
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                                                                          基本信息:

                                                                          姓名: 周天華
                                                                          職務: 主任
                                                                          職稱: 教授
                                                                          學歷: 博士
                                                                          專業: 細胞生物學、病理學與病理生理學
                                                                          所屬院系: 基礎醫學系
                                                                          研究方向: 分子細胞生物學、胃腸腫瘤學
                                                                          電話: 0571-88208009
                                                                          信箱: tzhou@zju.edu.cn
                                                                          個人主頁: http://mypage.zju.edu.cn/0005005

                                                                          個人簡介:

                                                                          周天華,博士 ,钱柜求是特聘教授,“國家傑出青年科研基金”獲得者  ,國家“萬人計劃”科技領軍人才,教育部“新世紀優秀人才計劃”獲得者、科技部“中青年科技創新領軍人才”,浙江省“錢江人才計劃”獲得者 ,浙江省重點科技創新團隊(胃腸疾病診治新技術創新團隊)首席科學家 ;兼任中國細胞生物學學會理事、中國細胞生物學學會青年委員會副主任委員、細胞結構與細胞行爲分會副會長、钱柜青年教授聯誼會副會長、Cell Research(影響因子14.8)、Journal of Experimental Clinical Cancer Research(影響因子4.8)等期刊編委。1988年起就讀於钱柜平台 ,1993年獲醫學學士學位 ,1996年獲臨牀醫學碩士學位  ,1999年畢業於中科院上海生命科學研究院獲博士學位 。2000年至2006年在美國哈佛大學分子細胞生物學系進行博士後訓練。現任钱柜學位評定委員會辦公室主任、學科建設處處長、钱柜平台細胞生物學與遺傳學系主任、分子醫學研究中心主任、醫學細胞生物學主講教師(http://mypage.zju.edu.cn/0005005) 。


                                                                          周天華博士在分子細胞生物學和分子腫瘤學領域具有比較紮實的理論知識和實踐基礎,長期從事細胞運動與細胞週期的分子調控及其在癌症發生發展中作用的研究,在細胞核分佈基因C(NudC)通路的分子調控領域中取得了突破性進展 。自1998年以來,已在《Dev Cell》(Cell 子刊)、《PNAS》(美國國家科學院院刊)和《J Biol Chem》等國際學術期刊發表了40篇原始學術論文  ,合計影響因子超過290,受到國際同行們的關注(他引超過1000多次) 。國際權威雜誌Nature Reviews Molecular Cell Biology曾經以新聞的方式報道過其工作 ,由世界知名生物醫學科學家組成的獨立同行評議服務機構Faculty of 1000,也專門推薦其研究成果 。2009年起,其領導的研究小組在細胞運動分子機理調控及癌症發生發展的細胞運動基礎等領域 ,取得了一些有價值的實驗結果 ,在《Cell Research》、《PNAS》和《J Biol Chem》等國際著名刊物上發表了一系列的原創性學術文章。近年來,作爲負責人擔任國家傑出青年科學基金1項、國家自然科學基金國際合作重點項目1 項、重點重大項目子課題1項、面上項目5項、973計劃項目課題和子課題各1項及其他多個項目,累計資助經費超過2000萬。獲浙江省科技進步一等獎一項、中華醫學科技獎三等獎一項、浙江省醫藥衛生科技創新獎一等獎一項、美國專利一項、中國專利一項(排名均在前三) 。入選浙江省“衛生高層次創新人才計劃”、浙江省“錢江人才計劃”、 浙江省“151人才計劃”(第一層次)等。

                                                                          實驗室網站:http://www.absolutefoot.net/molecule/GroupServe234.aspx
                                                                          課程網站:http://10.71.121.158/G2S/Template/View.aspx?action=view&courseType=1&courseId=27337&ZZWLOOKINGFOR=G)。

                                                                          主要學術兼職:
                                                                          Cell Research (最新影響因子10.5)編委
                                                                          中國細胞生物學學會理事
                                                                          中國細胞生物學學會青年委員會副主任委員
                                                                          中國細胞生物學學會細胞結構與功能分會副會長
                                                                          钱柜青年教授聯誼會副會長

                                                                          近年來發表主要SCI論文:
                                                                          作爲通訊作者和第一作者的主要論文(* 通訊作者):
                                                                          1. Shen M, Cai Y, Yang Y, Yan X, Liu X and Zhou T*. (2013). Centrosomal Protein FOR20 is essential for S-phase progression by Recruiting Plk1 to Centrosomes. Cell Research 23(11):1284-1295. doi:10.1038/cr.2013.127(最新影響因子: 10.526)published online 10 September 2013.
                                                                          2. Deng Y, Huang Z, Xu Y, Jin J, Zhuo W, Zhang C, Zhang X, Shen M, Yan X, Wang L, Wang X, Kang Y, Si J* and Zhou T*. (2013). MiR-215 modulates gastric cancer cell proliferation by targeting RB1. Cancer Letters  Aug 24. doi: 10.1016/j.canlet.2013.08.033. (最新影響因子: 4.23).
                                                                          3. Liu Y, Yan X and Zhou T*. (2013). TBCK Influences Cell Proliferation, Cell Size and mTOR Signaling Pathway. PLOS ONE 8(8): e71349. doi:10.1371/journal.pone.0071349 (最新影響因子3.73).
                                                                          4. Xu Y, Deng Y, Yan X and Zhou T*. (2011). Targeting miR-375 in gastric cancer. Expert Opinion on Therapeutic Targets 15(8):961-972.(當年影響因子: 3.716)
                                                                          5. Zhu X, Liu X, Jin Q, Cai Y, Yang Y and Zhou T*. (2010). The L279P Mutation of Nuclear Distribution Gene C (NudC) Influences Its Chaperone Activity and LIS1 Stability. Journal of Biological Chemistry 285(39):29903-29910. (當年影響因子: 5. 328)
                                                                          6. Ding L, Xu Y, Zhang W, Deng Y, Si M, Du Y, Hao H, Liu X, Si J* and Zhou T*. (2010). MiR-375 Frequently Down-regulated in Gastric Cancer Inhibits Cell Proliferation by Targeting JAK2. Cell Research 20(7):784-793. (當年影響因子: 9.417)
                                                                          7. Yang Y, Yan X, Cai Y, Lu Y, Si J and Zhou T*. (2010). NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. Proceedings of the National Academy of Sciences of the United States of America 107(8): 3499-3504.(當年影響因子: 9.771)
                                                                          8. Cai Y, Yang Y, Shen M and Zhou T*. (2009) Inhibition of cytokinesis by overexpression of NudCL that is localized to the centrosome and midbody. Cell Research 19(11):1305-1308. (當年影響因子: 8.151)
                                                                          9. Du Y, Xu Y, Ding L, Yao H, Yu H, Zhou T* and Si M*. (2009) Down-regulation of miR-141 in gastric cancer and its involvement in cell growth. Journal of Gastroenterology 44(6):556–561. (當年影響因子: 2.909)
                                                                          10. Zhou T, Zimmerman W, Liu X and Erikson RL. (2006). A Mammalian NudC-Like Protein Essential for Dynein Stability and Cell Viability. Proceedings of the National Academy of Sciences of the United States of America  103(24):9039-9044. (當年影響因子: 9.643)
                                                                          11. Zhou T,* Aumais J, Liu X, Yu-Lee, LY and Erikson, RL. (2003). A role for Plk1 phosphorylation of NudC in cytokinesis. Developmental Cell 5(1):127-138. (當年影響因子: 14.807)
                                                                          12. Zhou TH, Ling K, Guo J, Zhou H, Wu Y, Jing Q, Ma L and Pei G. (2000). Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. Journal of Biological Chemistry 275(4):2513-2519. (當年影響因子: 7.368))
                                                                          13. Wu GX,# Lin YM, # Zhou TH, # Gao H and Pei G. (2000). Significant down-regulation of alpha-albumin in human hepatoma and its implication. Cancer Letters 160(2), 229-236. (#共同第1作者 ,當年影響因子: 1.517)
                                                                          14. Zhou TH, Ren XH, Yin DL, Wu YL, Li M, Lu CZ, Wu DC, Wu YQ, Peng YQ, Wang YP, Ma L and Pei G. (1997). Retardation of pain development: a case of recovery from congenital insensitivity to pain. Acta Anaesthesiologica Scandinavica 41, 1077-1079. (當年影響因子: 1.953)


                                                                          作爲合作作者的主要論文:
                                                                          15. Shao CY, Zhu J, Xie YJ, Wang Z, Wang YN, Wang Y, Su LD, Zhou L, Zhou TH and Shen Y. (2013). Distinct Functions of Nuclear Distribution Proteins LIS1, Ndel1 and NudCL in Regulating Axonal Mitochondrial Transport. Traffic 14:785-797.(最新影響因子: 4.919)
                                                                          16. Wang L, Chen S, Xue M, Zhong J, Wang X, Gan L, Lam EK, Liu X, Zhang J, Zhou T, Yu J, Jin H and Si J. (2012). Homeobox D10 gene, a candidate tumor suppressor, is downregulated through promoter hypermethylation and associated with gastric carcinogenesis. Molecular Medicine 18(3):389-400(最新影響因子: 3.757)
                                                                          17. Yin Y, Li J, Chen S, Zhou T and Si J. (2012). MicroRNAs as Diagnostic Biomarkers in Gastric Cancer. Int J Mol Sci. 13(10):12544-12555. (最新影響因子: 2.598)
                                                                          18. Gan L, Chen S, Zhong J, Wang X, EK Lam, Liu X, Zhang J, Zhou T, Yu J, Si J, Wang L, and Jin H. (2011). ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer. PloS One  6(2): e16916. (當年影響因子: 4.092)
                                                                          19. Zhou Q, Lu X, Gan L, Chen S, Zhou T, Wang L and Si J. (2010). Role of REG Iα in gastric carcinogenesis: Gastrin-associated proliferative and anti-apoptotic activities. Molecular Medicine REPORORTS  3(6): 999-1005. (當年影響因子: 0.307)
                                                                          20. Li A, Zhou T, Guo L, Si J. (2010) Collagen type I regulates beta-catenin tyrosine phosphorylation and nuclear translocation to promote migration and proliferation of gastric carcinoma cells. Oncology Reports 23(5):1247-1255. (當年影響因子: 1.686)
                                                                          21. Zhao Y, Zhou T, Yao H, Hei F, Wang L and Si J. (2009) A Potential Role of Collagens Expression in Distinguishing between Premalignant and Malignant Lesions in Stomach. The Anatomical Record 292(5):692-700. (當年影響因子: 1.490)
                                                                          22. Chen Y, Chen Y, Liu WL, Zhou TH, Cai JT, Du Q, Wang LJ, Wu JG and Si JM. (2009). Therapeutic effects of rectal administration of muscovite on experimental colitis in rats. Journal Gastroenterology and Hepatology 24(5):912-919. (當年影響因子: 2.317)
                                                                          23.Pan H, Sheng JZ, Tang L, Zhu R, Zhou TH and Huang HF. (2008). Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients. Fertility & Sterility 90(4):1000-1007.(當年影響因子: 4.167)
                                                                          24. Li M, Zhou TH, Gao Y, Zhang N and Li JC. (2007). Ultrastructure and estrogen regulation of the lymphatic stomata of ovarian bursa in mice. The Anatomical Record 290(10):1195-1202. (當年影響因子: 1.800)
                                                                          25. Liu WL, Chen SJ, Chen Y, Sun LM, Zhang W, Zeng YM, Zhou TH and Si JM. (2007). Protective effects of heat shock protein70 induced by geranylgeranylacetone in atrophic gastritis in rats. Acta Pharmacology Sinica 28(7):1001-1006. (當年影響因子:1.67)
                                                                          26. Liu AX, Jin F, Zhang WW, Zhou TH, Zhou CY, Yao WM, Qian YL and Huang HF. (2006). Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss. Biology of Reproduction 75(3):414-420. (當年影響因子:3.498)
                                                                          27. Liu X, Lin CY, Lei M, Yan S, Zhou T and Erikson RL. (2005). CCT chaperonin complex is required for the biogenesis of functional Plk1. Molecular and Cellular Biology 25(12):4993-5010.(當年影響因子: 7.093)
                                                                          28. Liu X, Zhou T, Yan S and Erikson RL. (2004). Molecular interaction of polo-like kinase 1 with mitotic kinesin-like protein CHO1/MKLP-1. Journal of Cell Science 117(15):3233-3246. (當年影響因子: 6.910)
                                                                          29. Liu X, Yan S, Zhou T, Terada Y and Erikson RL. (2004). The MAP kinase pathway is required for entry into mitosis and cell survival. Oncogene 23(3): 763-776. (當年影響因子: 6.318)
                                                                          30. Wang P, Wu Y, Zhou TH, Sun Y and Pei G. (2000). Identification of alternative splicing variants of the beta subunit of human Ca (2+)/calmodulin-dependent protein kinase II with different activities. FEBS Letters 475(2):107-110. (當年影響因子: 3.440)
                                                                          31. Yu QM, Cheng ZJ, Zhou TH, Cen B, Guo SQ and Pei G. (1999). Molecular cloning of human beta arrestin1 cDNA, expression and function study. Acta Biochimica et Biophysica Sinica 31(3):344-346. (最新影響因子:1.807)
                                                                          32. Lou LG, Zhou T, Wang P and Pei G. (1999). Modulation of Ca2+/Calmodulin-Dependent Protein Kinase II Activity by Acute and Chronic Morphine Administration in Rat Hippocampus: Differential Regulation of  and  Isoforms. Molecular Pharmacology 55(3):557-563. (最新影響因子: 4.411)
                                                                          33. Yu QM., Cheng ZJ, Zhao J, Zhou TH, Wu YL Ma L and Pei G. (1998). Carboxyl terminal of rhodopsin kinase is required for the phosphorylation of photo-activated rhodopsin. Cell Research 8(4),:303-310. (最新影響因子: 10.526)
                                                                          34. Fan GH, Zhou TH, Zhang WB and Pei G. (1998). Suppression of Phospholipase C blocks Gi-mediated inhibition of adenylyl cyclase activity. European Journal of Pharmacology 341(2), 317-322. (最新影響因子: 2.592)
                                                                          35. Wu Y L, Fan GH, ZhaoJ, Zhou TH, Ma L and Pei, G. (1997). Functional expression of Opioid receptor-like Receptor and its endogenous specific agonist Nociceptin/Orphanin FQ during Mouse embryogenesis. Cell Research 7(2):207-215. (最新影響因子: 10.526)

                                                                          英文著作:
                                                                          1. Zhou, T. and Erikson, R.L. A role of Polo-like kinase 1 phosphorylation of NudC in cytokinesis. In Signal Transduction of Cell Division, T. Miki, ed. (Research Signpost). (2005).

                                                                          在美國基因數據庫(GenBank)登錄的基因:
                                                                          FJ215684 (Homo sapiens NudC-like protein 2),
                                                                          AF083420 (homo sapiens brain-specific STE20-like protein kinase 3, MST3b),
                                                                          AF078803 (homo sapiens calcium/calmodulin-dependent protein kinase 2 beta subunit),
                                                                          AF081924 (homo sapiens calcium/calmodulin-dependent protein kinase 2 beta 6 subunit),
                                                                          AF140350 (Homo sapiens calcium/calmodulin-dependent protein kinase II beta 7 subunit),
                                                                          AF083419 (homo sapiens calcium/calmodulin-dependent protein kinase beta 2 e subunit),
                                                                          AF081572 (homo sapiens calcium/calmodulin-dependent protein kinase 2 beta e’ subunit),
                                                                          AF091486 (homo sapiens calcium/calmodulin-dependent protein kinase 2 alpha subunit),
                                                                          AF084040 (homo sapiens beta-arrestin 1A),
                                                                          AF084940 (homo sapiens beta-arrestin 1B),
                                                                          AF106941 (homo sapiens beta-arrestin 2).

                                                                          相關獲獎成果:
                                                                          1、胃癌前病變癌變準確監測和有效阻斷技術體系的建立(2012年浙江省科技進步一等獎  ,排名第3/11)
                                                                          2、胃癌前病變癌變準確監測和有效阻斷技術體系的建立(2009年浙江省醫藥衛生科技創新一等獎、排名第3/11)
                                                                          3、胃癌前病變癌變準確監測和有效阻斷技術體系的建立(2009年中華醫學科技三等獎、排名第3/11)
                                                                          4、浙江省第六屆青年教師教學技能比賽優秀獎(2011年 ,浙江省青年教師大會特邀報告)
                                                                          5、钱柜青年教師教學技能比賽一等獎

                                                                          相關專利:
                                                                          1. 美國專利“Method for detecting liver cell in peripheral blood” (專利證書號:CN1331417-A,排名第三)
                                                                          2. 中國專利:一種檢測用生物標誌物及應用(專利證書號:ZL200810163151.3,排名第二)